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拉米夫定医药级 134678-17-4 南箭牌 厂家自产

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                                                                                                                                 拉米夫定                                    新型抗病毒药物 适应症 什么样的病人适合使用拉米夫定 恩替卡韦 药动学 停药 不良反应与副作用 禁用情况 MSDS 用途与合成方法 拉米夫定价格(试剂级) 上下游产品信息 新闻专题                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    中文名称:                                    拉米夫定                                    中文同义词:                                    (2R-顺式)-4-氨基-1-(2-羟甲基-1,3-氧硫杂环戊-5-基)-1H-嘧啶-2-酮;拉米夫定;拉米呋啶;拉夫米定;拉米呋定;拉米夫啶;(2R-顺式)-4-氨基-1-[2-(羟基甲基)-1,3-嘿噻烷-5-基]-2(1H)-嘧啶酮;(-)-1-[(2R,5S)-2-(羟基甲基)-1,3-氧杂蒂奥纶聚乙烯醇纤维-5-基]胞嘧啶                                    英文名称:                                    Lamivudine                                    英文同义词:                                    (-)-BCH-189;(-)-BETA-L-2',3'-DIDEOXY-3'-THIACYTIDINE;(-)-B-L-2',3'-DIDEOXY-3'-THIACYTIDINE;(2r-cis)-4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1h)-pyrimidinone;2'-deoxy-3'-thiacytidine;4-AMINO-1-((2R,5S)-2-HYDROXYMETHYL-[1,3]OXATHIOLAN-5-YL)-1H-PYRIMIDIN-2-ONE;3TC;3'-THIA-2',3'-DIDEOXYCYTIDINE                                    CAS号:                                    134678-17-4                                    分子式:                                    C8H11N3O3S                                    分子量:                                    229.26                                    EINECS号:                                                    相关类别:                                    Active Pharmaceutical Ingredients;Antivirals for Research and Experimental Use;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Anti-virals;Intermediates & Fine Chemicals;Pharmaceuticals;抗感染药物;医药与生物化工;抗微生物药物;抗病毒药物;API's;抗病源性微生物药;药物;HIV/AIDS/Related Products;Sulfur & Selenium Compounds;原料药;API;中间体;抗生素;DENDRID;医药中间体;抗病毒类药;人工合成抗感染类药;医药原料;小分子抑制剂;抗病毒药,用于肝胆疾病的治疗;抗病毒抗感染类                                    Mol文件:                                    134678-17-4.mol                                                                                                                                                                                                拉米夫定 性质                                                                                                                                                                                                                                                                                                                                                    熔点                                     177 °C                                    折射率                                     -142 ° (C=1, MeOH)                                    储存条件                                     Freezer                                    Merck                                     5352                                    CAS 数据库                                    134678-17-4(CAS Database Reference)                                                                                                                                                                                                                                                化学性质                             从甲醇-乙酸乙酯得白色固体。[α]D21-132°(C=1.08,甲醇)。或从沸乙醇结晶,熔点160~162℃。[α]D21-135°(C=0.38,甲醇)。                            用途                             抗病毒药,用于乙型肝炎。                            用途                             抗病毒药,用于肝胆疾病的治疗                            用途                             肝胆疾病用药。                            生产方法                             对化合物(Ⅰ)进行选择性6-O-磺酰化反应,接着乙酰化得到化合物(Ⅱ),收率96.7%。化合物(Ⅱ)以乙酸作溶剂,和3moL的溴化氢/L酸(45%,W/V)反应,溴化得到化合物(Ⅲ),收率99%。溴化物(Ⅲ)和3.3moI。的黄原酸乙酯钾盐,在丙酮中回流,硫代并环合;然后在甲醇中用氨水进行水解,得到化合物(Ⅳ),二步收率72%。化合物(Ⅳ)经柱层析提纯,为结晶性的固体。化合物(Ⅳ)用1.4摩尔的高碘酸钠处理,以使2,3-顺式二醇开环;接着用硼氢化钠还原形成的醛,并用形成缩酮的形式来保护二醇,得到化合物(V),收率60%。化合物(V)硅烷化以保护剩下的伯醇,再脱去缩酮,得到化合物(Ⅵ),收率63%。以四乙酸铅来氧化化合物(Ⅵ)中的二醇,再以二铬酸吡啶铺盐来进一步氧化,得到化合物(Ⅶ),该氧化方法不会影响硫。化合物(Ⅶ)再用四乙酸铅氧化,得到化合物(Ⅷ),收率66%[以化合物(Ⅵ)计]。化合物(Ⅷ)和(Ⅸ),在二氯乙烷中,用TMSOTf作为Lewis酸催化剂,缩合得到化合物(X),收率64%。另外还有化合物(X)的异构体,其量为化合物(X)的一半,它们可用硅胶层析来分离。化合物(X)以氨-甲醇来去乙酰基,收率73%;再以四正丁基氟化铵来脱硅烷化,即得到拉米夫定,收率75%。            "};

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